Ligand Binders against the Proteome
Uppsala, Sweden

Organisers:

Mike Taussig: The Babraham Institute, Cambridge, UK
Bernhard Korn: RZPD - Resource Center for Genome Research, Heidelberg, Germany
Ulf Landegren: Uppsala University, Sweden
Andreas Plückthun: Zurich University, Zurich

The post-genome proteomics objective is to detect, quantify and characterise all relevant proteins in tissues and fluids in health and disease. A solution is to generate a collection of specific ligand binders (antibodies, scaffolds, aptamers) against the proteome. This has been quite widely discussed in various circles (HUPO, EC, national) and the need for a binder collection at the European level is now well recognised. The problem is one of scale and the notion of 'completeness' is therefore a long-term aim and more immediately there may have to be a focus on particular protein categories. Applications of such a resource will include protein expression profiling, tissue distribution, disease mechanisms, biomarkers, diagnostics, etc. To draw an analogy with the human genome project, we are just at the stage of discussing the best strategies before thinking about how it would be organised.

Recently (September 2004) we held a successful ESF workshop on this subject cofunded with the FP6 Moltools consortium. A number of important areas were raised which, given their scope, will require further discussion (see workshop report). This second meeting is again jointly supported by MolTools. Important questions are:

• Can this project (a binder collection on a genome-wide scale) be made realistic at the technical level?
• What are the benefits?
• How should it be coordinated at the European level?

Venue:

Krusenberg Herrgard, Uppsala, Sweden

Dates:

13 - 15 June, 2005

Programme Outline:
Monday 13th June:
Arrival in afternoon
Dinner followed by evening session

Tuesday 14th June :
Full day session with a social event in the evening

Wednesday 15th June:
Full day session and departure

A full programme will be available here shortly.

Participants:

Sabine Baars, RCSI, Dublin
Carl Borrebaeck, Lund University
Andrew Bradbury, Los Alamos National Laboratory
Antoine de Daruvar, Centre de Bioinformatique, Bordeaux
Stefan Dübel, Technical University of Braunschweig
Jutta Eichler, GBF - German Research Centre for Biotechnology, Braunschweig
Björn Ekström, Olink AB, Uppsala
Tony Gibson, EMBL, Heidelberg
Larry Gold, Somalogic, Boulder, Colorado
Simone Günther, Applied Biosystems, Darmstadt
Sigrun Gustafsdottir, Rudbeck Laboratory, Uppsala University
Mingyue He, Babraham, Cambridge
Manuela Helmer-Citterich, University or Rome
Friedrich Herberg, Universität Kassel
Henning Hermjakob, European Bioinformatics Institute, Cambridge
Jörg Hoheisel, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg
Malin Jarvius, Rudbeck Laboratory, Uppsala University
Masood Kamali-M, Rudbeck Laboratory, Uppsala University
Farid Khan, Babraham, Cambridge
Paul Ko Ferrigno, Hutchison/MRC research centre, Cambridge
Zoltán Konthur, MolTools, Max Planck Institute for Molecular Biology, Berlin
Bernhard Korn, German Genome Resource Centre, RZPD, Heidelberg
Sylvia Krobitsch, Max Planck Institute for Molecular Biology, Berlin
Ulf Landegren, Rudbeck Laboratory, Uppsala University
Daniel Laune, CNRS-Biorad, Montpellier
Sophie Laurenson, Hutchison/MRC research centre, Cambridge
Ken Livak, Applied Biosystems, California
Rami Mäkelä, VTT Medical Biotchnology, Turku
John McCafferty, Sanger Institute, Cambridge
Serge Muyldermans, Vrije Universiteit, Brussels
Per-Åke Nygren, Royal Institute of Technology, Stockholm
Andreas Plückthun, Biochemisches Institut, Zurich University
Mina Pourmousa, Dept of Medical Sciences, Uppsala University
Michael Przybylski, University of Konstanz
Carolina Rydin, MolTools administrator, Rudbeck Laboratory, Uppsala
Petri Saviranta, VTT Medical Biotchnology, Turku
Alan Sawyer, EMBL, Monterotondo-Scalo
Edith Schallmeiner, Rudbeck Laboratory, Uppsala University
Darren Schofield, Sanger Institute, Cambridge
Arne Skerra, Lehrstuhl für Biologische Chemie, Freising-Weihenstephan
Jane Steel, Beatson Institute for Cancer Research, Glasgow
Mike Taussig, Babraham, Cambridge
Gholamreza Tavoosidana, Dept of Animal Development & Genetics, Uppsala University
Markus Templin, NMI, University of Tübingen
Mathias Uhlén, KTH Biotechnology, Stockhom
Silvère van der Maarel, Leiden University Medical Centre
Gert-Jan van Ommen, Leiden University Medical Centre
Matthias Wilm, EMBL, Heidelberg
Christer Wingren, Lund University
Roman Zubarev, Uppsala University

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