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Organisers
Mike Taussig, Babraham Insititute, Cambridge
Oda Stoevesandt, Babraham Institute, Cambridge
Cheryl Smythe, Babraham Institute, Cambridge
Stefan Dübel, Technical University of Braunschweig
Ulf Landegren, University of Uppsala
Introduction
An affinity proteomics approach is essential to the ambition of characterising the composition and function of proteomes of different species. In the case of the human proteome, this will be an enormous undertaking: compared with the ~24,000 genes, the existence of alternative splicings and post-translational modifications means that there are probably well over 10-times that number of individual protein species in the proteome. Defining such an enormous network is an essential task, for which it is fundamentally important to be able to detect, quantify and characterise all relevant proteins in tissues and fluids in health and disease. Affinity proteomics will require a systematic collection of specific binding reagents against all members of the proteome. While the most familiar affinity reagents are the classical antibodies and their fragments, there are also alternative engineered forms of novel protein scaffolds and nucleic acid aptamers with similar diversity and binding properties. This meeting will explore the technologies and reagents required for affinity proteomics, with participation of the ProteomeBinders consortium which brings together the foremost groups in Europe interested in different aspects of protein analysis.
The programme can be downloaded as a pdf here.
Sessions will cover:
• Overview of the human proteome - mass spectrometry of tissues, organelles and fluids; protein interaction networks
• Affinity proteomics resources - varieties of natural and recombinant antibodies; scaffolds, peptides and aptamers from combinatorial libraries; production and selection methods, incl molecular display systems
• Affinity proteomics tools - high throughput systems of protein expression analysis, including protein, cell and tissue arrays
• Applications - affinity based functional proteome analysis and potential disease applications in binder-based diagnostics and therapeutics
• Bioinformatics infrastructure - databases, ontologies and webpages for storage and distribution of the information on the properties for binders and their targets
• Planning for the future - how to organise a European Binders Resource under the EC Framework 7 Programme
Venue
The meeting will be held in the Congress Centre in the alpine village of Alpbach in the Austrian Tyrol where there are excellent skiing opportunities which will be incorporated into the programme.
Information & Registration
Registration: Registration is now closed.
Accommodation: A limited number of rooms are available for meeting participants in hotels within walking distance from the conference venue. Please use the accommodation form to book your accommodation directly with the Conference Centre in Alpbach.
Travel: Please refer to the Alpbach webpage for travel advice.
For further information please email Cheryl Smythe.
Speakers and chairs will include:
Andre Bernard (Buchs)
Carl Borrebaeck (Lund)
Andrew Bradbury (Los Alamos)
Dolores Cahill (Dublin)
Adam Clarke (Bethesda)
Eric Chevet (Bordeaux)
Stefan Dübel (Braunschweig)
Ronald Frank (Braunschweig)
Toby Gibson (Heidelberg)
Larry Gold (Boulder, CO)
Henning Hermjakob (Hinxton)
Jörg Hoheisel (Heidelberg)
Silvia Jimenez / Lydie Lane (Geneva)
Thomas Joos (Tubingen)
Ulf Landegren (Uppsala)
Thomas Laurell (Lund)
Heinrich Leonhardt (Munich)
Silvere van der Maarel (Leiden)
Serge Muyldermans (Brussels)
Christof Niemeyer (Dortmund)
Per Ake Nygren (Stockholm)
Gertjan van Ommen (Leiden)
Leena Peltonen (Helsinki)
Andreas Pluckthun (Zurich)
Terry Rabbitts (Cambridge & Leeds)
Arne Skerra (Munich)
Mike Taussig (Cambridge)
Marius Ueffing (Munich)
Mathias Uhlén (Stockholm)
Matthias Wilm (Heidelberg)
