Organisers

Kjetil Taskén, The Biotechnology Centre of Oslo, University of Oslo, Norway
Miles Houslay, IBLS, University of Glasgow, UK
Johannes Bos, University Medical Centre Utrecht, The Netherlands
Jacques Pouyssegur, Institute of Signalling, Developmental Biology and Cancer Research, Nice, France
Peter Downes, School of Life Sciences, University of Dundee, UK
John Scott, The Biotechnology Centre of Oslo, University of Oslo, Norway

Introduction

This meeting will address the spatiotemporal control of cellular events that proceeds through dynamically regulated multiprotein complexes. Information flow through these protein networks is finely tuned by the opposing activities of signal transduction and termination enzymes. The combination of new computational, proteomic, fluorescent imaging and structural biology techniques allows for analysis of how such dynamic protein networks propagate, process and disseminate second messenger signals at the molecular and cellular level. Moving from the concept of protein modules, the combinatorial assembly of multiprotein units is now explored. Cryoelectron microscopy and X-ray crystallography are used to define the structure of these higher order signalling complexes. Molecular imaging allows for deciphering the dynamic assembly of signalling complexes and second messenger signalling in situ. Molecular interaction techniques are exploited to make tools that can selectively perturb specific components of signal complexes. Single cell signal analyses combined with computational modeling can predict the ebb and flow of these signals within signal networks.

Draft Programme

Venue

The meeting will be organised in beautiful surroundings at the Soria Moria Conference Centre in the hills above Oslo and overlooking the city.

Registration

Registration is now closed.

Speakers

Philippe Bastiaens, Max-Planck-Institute for Molecular Physiology, Dortmund, Germany
Johannes Bos, University of Utrecht, Utrecht, The Netherlands
Marco Conti, University of California San Francisco, California, US
Ivan Dikic, University of Frankfurt, Frankfurt, Germany
Dario Diviani, University of Lausanne, Lausanne, Switzerland
Ian M. Donaldson, University of Oslo, Oslo, Norway
Peter Downes, University of Dundee, Dundee, Scotland
Margaret Frame, University of Edinburgh, Edinburgh, Scotland
Miles Houslay, University of Glasgow, Glasgow, Scotland
Carol MacKintosh, University of Dundee, Dundee, Scotland
Richard Marais, Institute of Cancer Research, London, England
Christopher Marshall, Institute of Cancer Research, London, England
Werner Müller-Esterl, University of Frankfurt Medical School, Frankfurt, Germany
Klaus Okkenhaug, Babraham Institute, Cambridge, England
Ruth Palmer, Umeå University, Umeå, Sweden
Tony Pawson, Samuel Lunenfeld Research Institute, Toronto, Canada
Jacques Pouyssegur, University of Nice, Nice, France
John Scott, Oregon Health&Science Institute, University of Portland, Oregon, US
Harald Stenmark, Norwegian Radium Hospital, Oslo, Norway
Kjetil Taskén, University of Oslo, Oslo, Norway
Anders Tengholm, University of Uppsala, Uppsala, Sweden
André Veillette, Institut de Recherches de Cliniques de Montréal, Montréal, Canada
Marc Vidal, Harvard Medical School, Boston, Massachussetts, US
Marian Walhout, University of Massachusetts Medical School, Worcester, MA, US
Art Weiss, University of California San Francisco, San Francisco, California, US
Manuela Zaccolo, University of Glasgow, Glasgow, Scotland