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Organisers
Sjef Verbeek, Leiden University Medical Center, Leiden, Netherlands
Jos Jonkers, Netherlands Cancer Institute, Amsterdam, Netherlands
Hein te Riele, Netherlands Cancer Institute, Amsterdam, Netherlands
Paul Krimpenfort, Netherlands Cancer Institute, Amsterdam, Netherlands
Els Robanus-Maandag, Leiden University Medical Center, Leiden, Netherlands
Marian van Roon, Amsterdam Medical Center, Amsterdam, Netherlands
Werner Muller, University of Manchester, Manchester, UK
Introduction
The 2007 Nobel Prize in Physiology or Medicine was awarded to Mario Capecchi, Martin Evans and Oliver Smithies for their discoveries of "principles for introducing specific gene modifications in mice by the use of embryonic stem cells." This technology, coined gene targeting, has resulted in the creation of scores of genetically engineered mice with targeted mutations (knockout mice), which have revolutionised biomedical research and provided important insight into human disease. Recent developments have resulted in improved mouse models with tissue-specific and/or inducible mutations (e.g. conditional knockout mice) and novel in vivo imaging strategies for phenotypic analysis of mutant mice. On the other hand the amount of knowledge, time and labour required for the generation of these highly sophisticated models has substantially increased. Progress in biomedical research will therefore substantially benefit from improvements in efficacy and success rate of the generation of genetically modified mouse models and their ensuing phenotypic analysis. The Fifth Workshops on Innovative Mouse Models (IMM2009) will foster the development and dissemination of advanced technologies in mouse engineering and in vivo imaging.
The Workshop on Innovative Mouse Models (IMM) is very important for fostering interactions between researchers and for building international networks within the field of molecular mouse genetics. For PhD students, postdocs and young group leaders it is not only important to be informed about the most recent developments in the field but also to contact directly European and American colleagues. The informal character of the workshop is very suitable for stimulating scientific interactions and networking. A unique feature of the Innovative Mouse Models workshops is that not only successes are presented but also failures which help to improve the complex technology. Active participation of young scientists occurs by means of about 10 oral presentations by PhD students and young postdocs and an extensive poster presentation.
Although the workshop is open to all scientist interested in the topic without selection, we aim to maintain the low scale and informal character of the workshop. The number of participants is therefore limited to a maximum of 200.
Besides supporting direct interactions and collaborations the workshop is also focusing on innovation. Additional information on these four previous workshops can be found on the workshop website ( http://workshop.nki.nl)
Please download the programme as a pdf here.
Anton Berns (Netherlands Cancer Institiute, Amsterdam, Netherlands)
Adam Dupuy (University of Iowa, USA)
Andras Nagy (Mount Sinai Hospital, Toronto, Canada)
Barry Rosen (Wellcome Trust Sanger Institute, Hinxton, UK)
Austin Smith (Wellcome Trust Centre for Stem Cell Research, Cambridge, UK)
Francis Stewart (TU Dresden, Germany)
Lars Zender (Helmholtz Centre for Infection Research, Braunschweig , Germany)
The workshop will be held at the Leiden University Medical Center (LUMC) in Leiden, the Netherlands. The LUMC is located within walking distance from the railway station, at twenty train minutes from Amsterdam International Airport (Schiphol). All main cities are within easy reach: Amsterdam 37 km, The Hague 25 km and Rotterdam 50 km.
Leiden is a historical place with the oldest University in The Netherlands, founded in 1575. The 17th century historic city centre offers many objects of interest, such as canals, patrician houses, churches and museums.
Registration
Registration is now closed.
