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Visualising Biological Data - VIZBI 2010
3-5 March 2010
Heidelberg, Germany

Organisers
Report
1. Summary
2. Scientific content
3. Assessment of the results & impact of the event
4. Programme

Organisers:

Sean O'Donoghue, EMBL, Heidelberg, Germany
Nils Gehlenborg, EMBL-EBI, Cambridge, UK
James Procter, University of Dundee, Dundee, UK
Reinhard Schneider, EMBL, Heidelberg, Germany

Draft Report

Summary

The goal of VIZBI workshop was to bring together researchers developing and using visualisation systems across a wide area of biological disciplines. This was the first meeting of its kind, and it took place 3-5 March 2010 at the EMBL in Heidelberg, Germany. The workshop was attended by 113 participants, 30 speakers and 4 organisers -147 people in total. The meeting reviewed the state-of-the-art and challenges in visualising biological data across a wide range of fields, in particular genomics, sequence alignment and phylogeny, systems biology, 3D structures, optical microscopy, and MRI. The workshop had many concrete and positive outcomes, including the following: a collection of authoritative reviews spanning the field; the establishment of a website that draws together information and resources on visualisation in biology; a community effort to maintain a group of Wikipedia pages that collection further information on biological visualization tools; videos and Powerpoint/Keynote files of the presentations at VIZBI 2010. The meeting received very positive feedback from meeting participants, which was documented by anonymous collection by the EMBO. Full details of VIZBI 2010, including the programme, posters, etc. are available at the VIZBI website - http://vizbi.org.

Scientific Content

At the end of the VIZBI 2010 workshop, a final session was devoted to summarising and
reviewing the topics and issues raised in the workshop. This discussion is available in bullet-point form at: http://vizbi.org/2010/Talks/Closing_Remarks.pdf

In addition, a commentary publication was prepared as part of this workshop, primarily authored by the organisers and session chairs of VIZBI. The commentary provides a concise summary of the issues covered in the workshop, in three printed pages:

• O'Donoghue SI, Gavin A-C, Gehlenborg N, Goodsell DS, Hériché J-K, Nielsen CB,
North C, Olson AJ, Procter JB, Shattuck DW, et al: Visualizing biological data
-now and in the future. Nature Methods 2010, 7:S2-S4.
http://www.nature.com/nmeth/journal/v7/n3s/full/nmeth.f.301.html

Finally, the speakers have prepared a series of reviews that span the scientific content of the meeting in details:

1. Nielsen CB, Cantor M, Dubchak, I., Gordon D, Wang T: Visualizing Genomes: Techniques and Challenges. Nature Methods 2010, 7:S5-S15.
http://www.nature.com/nmeth/journal/v7/n3s/full/nmeth.1422.html

2. Procter JB, Barton GJ, Thompson J, Westhof E, Creevey C, Letunic I: Visualization of multiple alignments, phylogenies and gene family evolution. Nature Methods 2010, 7:S16-S25. http://www.nature.com/nmeth/journal/v7/n3s/full/nmeth.1434.html

3. Walter T, Shattuck D, Baldock R, Bastin M, Carpenter AE, Duce S, Ellenberg J, Fraser A, Hamilton N, Pieper S, et al: Visualization of image data from cells to organisms. Nature Methods 2010, 7:S26-S41.
http://www.nature.com/nmeth/journal/v7/n3s/full/nmeth.1431.html

4. O'Donoghue SI, Goodsell DS, Frangakis AS, Jossinet F, Laskowski R, Nilges M, Saibil HR, Schafferhans A, Wade R, Westhof E, Olson AJ: Visualization of macromolecular structures. Nature Methods 2010, 7:S42-S55.
http://www.nature.com/nmeth/journal/v7/n3s/full/nmeth.1427.html

5. Gehlenborg N, O'Donoghue SI, Baliga NS, Goesmann A, Hibbs MA, Kitano H, Kohlbacher O, Neuweger H, Schneider R, Tenenbaum D, Gavin A-C: Visualization of Omics Data for Systems Biology. Nature Methods 2010, 7:S56-S68.
http://www.nature.com/nmeth/journal/v7/n3s/full/nmeth.1436.html

Assessment of the results & impact of the event on the future direction of the field

As mentioned above, the workshop produced a series of authoritative review articles in a special issue of Nature Methods (available online at http://www.nature.com/nmeth/journal/v7/n3s/index.html). The special issue has
attracted considerable interest in the community, and was also featured prominently on
the Nature and Nature Biotechnology websites. A further two articles have been
commissioned by Nature Methods and EMBO Reports.

Based on the strong and positive feedback and reception of the meeting, we planning to
extend this meeting into a workshop series which would alternate each year between
Europe and the USA.

Programme

Wednesday 3 March 2010

08:30 - 09:30 Registration
09:30 - 09:40 Welcome Remarks (Seán O'Donoghue)

Visualization in Magnetic Resonance Imaging
Session Chair: David Shattuck

09:40 - 10:05 Quantitative Tissue Imaging with µ-MRI (Suzanne Duce)
10:05 - 10:30 Visualizing Anatomy and Function from MRI Data (Steve Pieper)
10:30 - 11:00 Coffee Break
11:00 - 11:30 Visualizing Brain White Matter using Diffusion MRI (Mark Bastin)
11:30 - 12:00 Visualization of Cardiovascular Function with MRI at Ultra-Short Timescales (Juergen Schneider)
12:00 - 12:30 Poster Fast-forward 'W'
12:30 - 14:00 Lunch Break + Poster Session 'W'

Visualization of Optical Microscopy Data
Session Chairs: Thomas Walter & Jean-Karim Heriche
Session Sponsor: ELIXIR

14:00 - 14:30 2D High-Throughput Microscopy Screens (Anne Carpenter)
14:30 - 15:00 High-Throughput & High-Content Quantitative Microscopy Data from Living Cells (Jan Ellenberg)
15:00 - 15:30 Coffee Break
15:30 - 16:00 Querying & Mapping External Data on 3D Image Datasets (Mark Ragan & Nick Hamilton)
16:00 - 16:30 Large Biological Samples Imaged with High-Resolution Microscopy (Pavel Tomancak)
16:30 - 17:00 Spatial Annotation & Query of Embryo Atlas Resources (Richard Baldock)
17:00 - 17:30 Coffee Break
17:30 - 18:30 Keynote: Visualizing Data (Ben Fry)
18:30 - 21:00 Dinner

Thursday 4 March 2010

Visualization in Systems Biology
Session Chairs: Anne-Claude Gavin & Nils Gehlenborg
Session Sponsor: ENFIN
09:00 - 09:30 Visualization Approaches for Gene Expression Data (Matthew Hibbs)
09:30 - 10:00 From Spectra to Networks - Visualizing Proteomics Data (Oliver Kohlbacher)
10:00 - 10:30 Metabolomics Data (Alexander Goesmann)
10:30 - 11:00 Coffee Break
11:00 - 11:30 Rapid Inference and Re-engineering of Biological Circuits (Nitin Baliga)
11:30 - 12:00 Biochemical Networks (Hiroaki Kitano)
12:00 - 12:30 Poster Fast-forward 'T'
12:30 - 14:00 Lunch Break + Poster Session 'T'
14:00 - 15:00 Keynote: Usability & Evaluation (Chris North)
15:00 - 15:30 Coffee Break

Visualization of Sequence Assemblies & Genomes
Session Chair: Cydney Nielsen

15:30 - 16:00 Sequencing & Assembly Finishing (David Gordon)
16:00 - 16:30 Genome Browsers (Ting Wang)
16:30 - 17:00 Comparative Genomics (Inna Dubchak)
17:00 - 17:30 Coffee Break
17:30 - 18:30 Science & Society Keynote: Communicating Science Visually (Bang Wong)
18:30 - 18:35 VIZBI Prize Award
18:35 - 23:00 Social evening + Dinner + Live music from 'Lily & Co' and 'Rejana Soul'

Friday 5 March 2010

Visualization of Macromolecular Structures
Session Chair: Seán O'Donoghue
09:00 - 09:30 Proteins (Michael Nilges)
09:30 - 10:00 Ligand Binding Sites (Roman Laskowski)
10:00 - 10:30 RNA (Eric Westhof)
10:30 - 11:00 Coffee Break
11:00 - 11:30 Molecular Dynamics (Rebecca Wade)
11:30 - 12:00 Electron Microscopy & Multi-scale Assemblies (Helen Saibil)
12:00 - 12:30 Poster Fast-forward 'F'
12:30 - 14:00 Lunch Break + Poster Session 'F' (Sponsor: Scottish Bioinformatics Forum)

Visualization of Alignments & Phylogenies
Session Chair: James Procter

14:00 - 14:30 Alignment Visualization (Geoff Barton)
14:30 - 15:00 Gene & Function Evolution (Julie Thompson)
15:00 - 15:30 Coffee Break
15:30 - 16:00 Phylogenetics (Ivica Letunic)
16:00 - 16:30 Concluding Remarks (Session Chairs)