|
Molecular
interactions: New frontiers for computational methods
Report
List of participants
List
of Instructors
Photos
Organiser:
Prof. Anna Tramontano
Department of Biochemical Sciences
University of Rome "La Sapienza"
P.le A. Moro, 5
00185 Rome
Tel: +39 06 49910556
Fax: +39 06 49910717
Report
(draft)
Scientific
content of the event
Genomic
information can be seen as the first catalogue of building
blocks for the challenging task of understanding the functions
of the genes and proteins within their situation in networks
and pathways. Protein interactions are a first key step in
this direction, and a basic component for addressing, in the
future, more complex problems related to complex genetic regulatory
mechanisms. Proteins can interact between themselves or with
other entities (substrates, cofactors, inhibitors) and the
study of these interactions can be of two types:
If
the structure of both interacting molecules is known, the
main focus is on the physical basis of their interaction.
The questions addressed are then related with the determination
of the regions of interaction between proteins, and the reconstitution
of the physical structure of the complexes. A special part
of this problem is the binding of small molecules to proteins,
which is particularly relevant for biochemical function and
as the basis for rational drug-binding projects.
In the absence of well defined structures, the main lines
of research are devoted to the determination of the interaction
partners and components of macromolecular complexes from sequence
information alone.
Participants
| Name |
Address |
E-mail |
Oxana
Galzitskaya
|
Institute
of
Protein Research, RAS, Pushchino,
Moscow Region Russia |
|
| Francesca
Vasile |
Dipartimento Scientifico Tecnologico,
Facoltà di Scienze MM. FF. NN.,
Università degli Studi di Verona
Strada Le Grazie 15, Cá Vignal 1, 37134 Verona,
Italy
|
vasile@sci.univr.it |
| Paolo
Benedetti |
Dipartimento di Chimica
Universita' degli Studi di Perugia
Via Elce di Sotto, 8
06123 Perugia
Italy
|
paolo@miasrl.com |
| Emma
Hill |
Structural
Studies Division
MRC Laboratory of Molecular Biology
Hills Road, Cambridge, CB2 2QH, UK
Tel:+44 (0) 1223 248011
Fax:+44 (0) 1223 213556
|
eeh@mrc-lmb.cam.ac.uk |
| Alice
Walker-Taylor |
Bioinformatics
Unit,
Computer Science Dept, University College London
Gower Street, London WC1E 6BT
|
Alice.Walker-Taylor@cs.ucl.ac.uk |
| Alessandra
Fano |
Universita' di Bari
Facolta' di Farmacia, Dipartimento Farmaco-Chimico
via Orabona 4, 70125 Bari, Italy
0039 0805442638
|
alessandrafano@farmchim.uniba.it |
| Julie
Bernauer |
LEBS
(Public Research Institute),
Bat 34, 1 allee de la Terrasse
91198 Gif-sur-Yvette
France
|
|
| David
Alejandro de Juan |
Protein
Design Group
National Center of Biotechnology
28049 Campus Universidad Aut.noma. Cantoblanco, Madrid
Spain.
Tel: (+34) 91 585 46 69
Fax: (+34) 91 585 45 06
|
dajs@cnb.uam.es |
| Romina
Oliva |
Dipartimento di Chimica
Complesso Universitario di M. S Angelo, Universita' degli
Studi di Napoli "Federico II", Via Cintia, 80126
- Napoli
Italia
Tel. +39-081-674288(96)
FAX +39-081-674090
|
romina@chemistry.unina.it |
| Manuela
Lopez de la Paz |
EMBL-Heidelberg
Meyerhofstrasse 1 D-69117 Heidelberg,
Germany
Tel. +49 (0) 6221 387 387
Fax. +49 (0) 6221 387 306
|
delapaz@embl-heidelberg.de |
| Valeria
Menchise |
Valeria
Menchise
Istituto di Biostrutture e Bioimmagini via Mezzocannone
6/8
80134, Napoli
Italy
Tel. ++39-081-2536650
|
|
| Maddalena
Catalano |
Lab. NMR
Istituto Chimica Macromolecole- CNR
via Ampere 56 20131 Milano
Tel. +39-0270643554
Fax +39-0270643557
|
madda@icmnmr.mi.cnr.it |
| Marco
Franceschin |
,
PhD student Rome "La Sapienza"
Tel: 0635508478 / 3384491122
Fax: 0635508478
|
marcofranceschin@libero.it |
| Raul
Mendez Giralde |
Service
de Conformation des Macromolecules Biologiques
et de Bioinformatique.
Unversite Libre de Bruxelles Av. F.D. Roosevelt 50
CP 160/16 B - 1050 Bruxelles BELGIQUE.
Tel. +32 2 650 2053
Fax. +32 2 648 8954
|
raul@ucmb.ulb.ac.be |
| Matthew
Bashton |
Structural
Studies Division
MRC Laboratory of Molecular Biology
Hills Road Cambridge CB2 2QH UK
Tel:+44 (0) 1223 248011
Fax:+44 (0) 1223 213556
|
bashton@mrc-lmb.cam.ac.uk |
| Antonello
Merlino |
Department
of Chemistry
University of Naples 'Federico II'
Complesso Universitario di Monte S'Angelo
Via Cinthia. 80126 Napoli Italy
Tel. +39 081674269
Fax. +39 081674090
|
merlino@chemistry.unina.it |
| Gioia
Altobelli |
University
of Rome "La Sapienza"
|
gioalt@hotmail.com |
| Silvio
Tosatto |
CRIBI
Biotechnology Centre
Universita' di Padova
V.le G. Colombo 3, I-35121 Padova Italy
Tel.: +39 49 8276165
Fax.: +39 49 8276159
|
silvio@cribi.unipd.it |
| Claudia
Bonaccini |
Dipartimento di Scienze Farmaceutiche
Universita' degli Studi di Firenze
Via G. Capponi 9 50121 Firenze Italy
Tel +39 055 2757303
Fax +39 055 240776
|
claudia.bonaccini@unifi.it |
| Giacomo
De Mori |
Istituto
di Chimica del Riconoscimento Molecolare (CNR)
(Public Research Institute)
via Mario bianco 9 20131 Milano Italy
Tel. 02/28500031
|
g.demori@ico.mi.cnr.it |
| Antonio
Riccio |
Institute
of Protein Biochemistry,
Via Marconi, 10 80125 Naples Italy
Tel. 0817257234
Fax. 0812396525
|
|
| Bernardetta
Addis |
Dipartimento
di Sistemi e Informatica, University of Florence
via di Santa Marta, 3, 50139 Firenze Italy
+39 055 4796 464
+39 055 4796 363
|
b.addis@ing.unifi.it |
| Janusz
M. BujnickI |
Molecular
Evolution Group
Bioinformatics Laboratory
International Institute of Molecular and Cell Biology
ul. ks. Trojdena 4, 02-109 Warsaw Poland
tel: +48-22 668 5384
fax: +48-22 668 5288
|
|
| Matthew
Couch |
Discovery
Informatics
Inpharmatica
60 Charlotte St
London W1T 2NU
Direct Line: 020 7074 4633
fax: +44 (0)20 7074 4700
|
m.couch@inpharmatica.co.uk |
| Richard
Bickerton |
Discovery
Informatics
Inpharmatica
60 Charlotte St, London W1T 2NU
Direct Line: 020 7074 4633
fax: +44 (0)20 7074 4700
|
r.bickerton@inpharmatica.co.uk |
| Mikko
Juhani Vainio |
Juvantia
Pharma Ltd.
Lemminkaisenkatu 5 (PharmaCity)
FIN-20520 Turku
Finland
p. +358-2-6517-1524
fax +358-2-6517-1599 |
mikko.vainio@juvantia.com |
| Joe
Sheridan |
Proteom
Ltd
Babraham Hall
Babraham Cambridge CB2 4AT
|
|
| Roberta
Bosotti |
Pharmacia
Biology dep. viale Pasteur 10
20014 Nerviano (MI)
Italia
Tel. 02-48383792
Fax. 02-48383755 m
|
roberta.bosotti@pharmacia.co |
| Giuseppe
Digilio |
Bioindustry Park del Canavese
Laboratorio Integrato di Metodologie Avanzate
Via Ribes 5, I-10010, Colleretto Giacosa (TO)
Tel: 0125 538346; Fax: 0125 53028
|
chemlima@bioindustrypark.it |
Instructors
| Prof.
Anna Tramontano |
Department
of Biochemical Sciences
University of Rome "La Sapienza"
P.le A. Moro, 5
00185 Rome
Tel: +39 06 49910556
Fax: +39 06 49910717
|
Anna.tramontano@uniroma1.it |
| Dr.
Veronica Morea |
Department
of Biochemical Sciences
University of Rome "La Sapienza"
P.le A. Moro, 5
00185 Rome
Tel: +39 06 49910556
Fax: +39 06 49910717
|
Veronica.morea@uniroma1.it |
| Prof.
David Jones |
Bioinformatics
Unit,
Dept. of Computer Science
University College
Gower Street, London WC1E 6BT, U.K.
Fax: +44 20 73871397
Tel: +44 20 76797981
|
David.Jones@cs.ucl.ac.uk |
| Prof.
Henriette Molinari |
Dipartimento
Scientifico Tecnologico,
Facoltà di Scienze MM. FF. NN.,
Università degli Studi di Verona
Strada Le Grazie 15, Cá Vignal 1, 37134 Verona,
Italy
Phone: ++39-045-8027949/8027906
Fax: ++39-045-8027929
|
henry@icmnmr.mi.cnr.it |
| Prof.
Roberto Giacobazzi |
Dipartimento
Scientifico Tecnologico,
Facoltà di Scienze MM. FF. NN.,
Università degli Studi di Verona
Strada Le Grazie 15, Cá Vignal 1, 37134 Verona,
Italy
Phone: 045 8027995
|
giacobazzi@sci.univr.it
|
| Dr.
Guido Gonzato |
Dipartimento
Scientifico Tecnologico,
Facoltà di Scienze MM. FF. NN.,
Università degli Studi di Verona
Strada Le Grazie 15, Cá Vignal 1, 37134 Verona,
Italy
Phone: 045 8027990
|
guido.gonzato
@univr.it
|
| Prof.
Alfonso Valencia |
Protein
Design Group, CNB-CSIC
Centro Nacional de Biotecnologia,Cantoblanco Madrid
28049 Spain
phone +34 915854570
fax: +34 915854506
|
valencia@cnb.uam.es |
| Prof.
Arthur Lesk |
Haematology
Department
University of Cambridge
Cambridge CB2 1TN, UK
Tel: 01223 336 829
|
aml2@mrc-lmb.cam.ac.uk |
| Dr.
Cyrus Chothia |
Structural
Studies Division,
MRC Laboratory of Molecular Biology,
Hills Road, Cambridge,
CB2 2QH, UK.
Tel:+44 (0) 1223 248011
Fax:+44 (0)1223 213556
|
chc1@mrc-lmb.cam.ac.uk |
| Dr.
Christos Ouzounis |
Computational
Genomics Group, Research Programme, The European Bioinformatics
Institute, EMBL Cambridge Outstation, Cambridge CB10
1SD, UK
|
ouzounis@ebi.ac.uk |
| Prof.
Mike Sternberg |
Imperial
College Centre for Bioinformatics
Biochemistry Building
Dept of Biological Sciences
Imperial College, London SW7 2AZ,UK
Tel +44-(0)20-7594-5212
Fax +44-(0)20-7594-5264
|
m.sternberg@ic.ac.uk |
| Dr.
Uwe Koch |
IRBM
Via Pontina Km 30.600
00040 Pomezia
Tel: +39 06 910931
Fax: +39 06 91093225
|
uwe_koch@merck.com |
| Dr.
Silvio Mecucci |
Dipartimento
di Chimica
Universita' degli Studi di Perugia
Via Elce di Sotto, 8
06123 Perugia
Italy
|
silvio@chemiome.chm.unipg.it |
| Prof.
Joel Janin |
Laboratoire
d'Enzymologie et Biochimie Structurales
CNRS 91198-Gif-sur-Yvette, France
tel 33.1.69 82 34 77 fax 33.1.69 82 31.29
http://www.lebs.cnrs-gif.fr/
|
janin@lebs.cnrs-gif.fr
|
Photos
|
